Vitamin C (ascorbic acid)- Ascorbic acid is a water-soluble vitamin found in fruits and vegetables such as citrus fruits and green peppers. It occurs as a white or slightly yellow crystal or powder with a slight acidic taste. It is an antiscorbutic product. On exposure to air and light it gradually darkens. In the dry state it is reasonably stable in air, but in solution it rapidly oxidizes. Ascorbic acid is a free radical, an antioxidant scavenger, and plays a major role in oxidation-reduction reactions. Ascorbic acid is a cofactor for enzymes involved in the biosynthesis of collagen (essential for tissue maintenance and repair), carnitine, and neurotransmitters. Humans cannot synthesize ascorbic acid endogenously and a lack of dietary intake can lead to scurvy. Vitamin C is most frequently used as a nutritional supplement. It also is used as an adjunct treatment of idiopathic methemoglobinemia and with deferoxamine in the treatment of chronic iron toxicity. Ascorbic acid has been used for a variety of ailments including the common cold, gum infections, acne, depression, fertility, and cancer; however, these claims have not been substantiated and vitamin C is not recommended for these purposes (see Mechanism of Action). Ascorbic acid was approved by the FDA in 1939.

Magnesium- Magnesium is the second most abundant intracellular cation. It is has been identified as a cofactor in more than 300 enzymatic reactions involving energy metabolism and protein and nucleic acid synthesis. Several magnesium salts are used clinically. Magnesium chloride, magnesium gluconate, magnesium lactate, and magnesium oxide are oral products used for supplementation in patients with magnesium deficiency due to malnutrition, restricted diet, alcoholism, or magnesium-depleting drugs. Magnesium oxide may also be used as an antacid or laxative. Magnesium sulfate is the most commonly used of the magnesium salts and can be administered orally or parenterally. It is used orally as a laxative and parenterally as a neuromuscular depressant or to treat hypomagnesemia. Oral magnesium sulfate belongs to the class of saline laxatives, which are used primarily to empty the bowel before surgery or radiologic, proctoscopic, or sigmoidoscopic procedures. Magnesium sulfate is also a useful cathartic in combination with charcoal to treat acute drug overdose because charcoal will not bind inorganic compounds like magnesium sulfate. The primary use of parenteral magnesium sulfate is to prevent and control seizures in preeclampsia and eclampsia. Parenteral magnesium sulfate is also useful in controlling seizures due to epilepsy, glomerulonephritis, or hypothyroidism. Parenteral magnesium may also be considered in the treatment of cardiac glycoside-induced arrhythmias. The 2000 ECC/AHA guidelines conclude that IV magnesium during cardiopulmonary rescuscitation has shown effectiveness only for the treatment of patients with hypomagnesemic states or polymorphic ventricular tachyardia (torsade de pointes).1Therefore, IV magnesium is not recommended in cardiac arrest except in suspected hypomagnesemic states or for the treatment of torsade de pointes.1 The routine prophylactic use of magnesium in patients with acute myocardial infarction is no longer recommended.1 Magnesium sulfate was officially approved by the FDA in 1939.

B-Complex- Vitamin B-Complex 100 Injection is a sterile solution for intramuscular or slow intravenous injection comprised of vitamins which may be categorized as belonging to the vitamin B complex group. Each mL contains: Thiamine Hydrochloride 100 mg, Riboflavin 5’ Phosphate Sodium 2 mg, Pyridoxine Hydrochloride 2 mg, Dexpanthenol 2 mg, Niacinamide 100 mg, with Benzyl Alcohol 2% as preservative, in Water for Injection. Sodium Hydroxide and/or Hydrochloric Acid may be used to adjust pH. Indications: In disorders requiring parenteral administration of vitamins, i.e. pre- and post-operative treatment, when requirements are increased as in fever, severe burns, increased metabolism, pregnancy, gastrointestinal disorders interfering with intake or absorption of vitamins, prolonged or wasting diseases, alcoholism and where other deficiencies exist.

B-12- Cyanocobalamin, or vitamin B12, is a B-vitamin. It is found in a variety of foods such as fish, shellfish, meats, and dairy products. Although cyanocobalamin and vitamin B12 are terms used interchangeably, vitamin B12 is also available as hydroxocobalamin, a less commonly prescribed drug product (see Hydroxocobalamin monograph). Cyanocobalamin is available nasally, orally, and parenterally, and is equal in biologic activity to hydroxocobalamin. Cyanocobalamin is used to treat pernicious anemia and vitamin B12 deficiency, as well as to determine vitamin B12 absorption in the Schilling test. Vitamin B12 is an essential vitamin found in the foods such as meat, eggs, and dairy products. Deficiency in healthy individuals is rare; the elderly, strict vegetarians (i.e., vegan), and patients with malabsorption problems are more likely to become deficient. If vitamin B12 deficiency is not treated with a vitamin B12 supplement, then anemia, intestinal problems, and irreversible nerve damage may occur. Oral therapy is not always effective, as some persons lack intrinsic factor, an endogenous substance produced by the stomach and necessary for oral B12 absorption. Other patients may not be able to absorb oral vitamin B12 due to surgical removal or dysfunction of the intestines in the area where absorption of vitamin B12 occurs. Thus, parenteral or nasal therapy may be needed; however, intranasal therapy should only be instituted for maintenance treatment after control of the condition has been obtained by the parenteral route. Vitamin B12 is used to treat pernicious anemia and vitamin B12 deficiency, as well as to determine vitamin B12 absorption in the Schilling test. Cyanocobalamin was approved by the FDA in 1949. The intranasal metered gel solution form (Nascobal®) was approved in November 1996 for vitamin B12 deficiency resulting from various conditions; in 2002, such conditions were expanded to include use in vitamin B12-deficient patients with HIV infection, AIDS, or Crohn's disease. An intranasal spray solution of B12, also called Nascobal®, with the same indications, was FDA approved in January 2005. Another intranasal spray, CaloMist™, was approved July 2007 for maintenance therapy after normalization with IM vitamin B12.

Glutathione- Glutathione (GSH) is composed of three amino acids combined to produce a peptide that is both a powerful antioxidant and performs several critical roles in the body. According to researchers this peptide is so essential to optimum health that the level of Glutathione in cells could possibly be used to predict how long an organism lives.12 Glutathione catalyzes glutathione S-transferases (GST) and glutathione peroxidases (GPx). Thus, playing a role in detoxification by eliminating toxic electrophilic molecules and reactive peroxides. Glutathione plays a crucial role in a detoxification system that is fundamental in plants, mammals, and fungi.3 Aside from its detoxification role it is important for a variety of essential cellular reactions. Its presence in the glyoxalase system, is fundamental to DNA and RNA nucleotide reduction. Glutathione is also a constituent in the regulation of protein and gene expression, exchange reactions including thiol to disulfide ratios involve glutathione.4 Glutathione can exist intracellularly in either an oxidized (glutathione disulfide) or reduced (glutathione) molecular state. The ratio of reduced glutathione to glutathione disulfide has been shown to be critical in cell survival, this system is very tightly regulated. Deficiency of glutathione puts the cell at risk for oxidative damage. An imbalance of glutathione is present in many pathologies including cancer, neurodegenerative disorders, cystic fibrosis (CF), HIV and aging. While Glutathione is vitally essential to maintaining a healthy immune system, it isn’t classified as an essential nutrient; this is because the body does create its own supply from the amino acids:

  • L-cysteine

  • L-glutamic acid

  • Glycine

One of the reasons why Glutathione is so important for optimum health is that it’s present in every cell in the body. One way antioxidants like glutathione help maintain good physical health is by neutralizing free radicals, which can cause cellular damage through oxidation. Since glutathione is naturally present within all types of cells, it is in a prime position to do this.  It’s considered one of the most important antioxidants in the human body.

L-Carnitine- Levocarnitine (L-3-hydroxy-4-N-trimethylaminobutyrate) is synthesized in the liver from the amino acids methionine and lysine. This naturally occurring substance is found in all mammalian tissues, especially striated muscle, and is required in energy metabolism, such as the oxidation of fatty acids, facilitating the aerobic metabolism of carbohydrates, and enhancing the excretion of certain organic acids. While only the L isomer is present in the biologic system, commercial synthesis of carnitine produces a D,L racemic mixture, from which the L-isomer is obtained. The D-isomer has pharmacologic effects but does not participate in lipid metabolism. Commercially, carnitine is available as both a prescription and non-prescription product. The prescription version is levocarnitine, while most dietary supplements contain D,L-carnitine which is commonly sold in health food stores. Levocarnitine has been used in the treatment of primary and secondary carnitine deficiency in adults and neonates, Alzheimer's disease, dilated cardiomyopathy in adults and children, valproic acid-induced hepatotoxicity in children, and hyperlipoproteinemia. It has been designated an orphan drug for a variety of conditions. Its use in alcohol induced fatty liver, Down's syndrome, and chronic fatigue syndrome has shown varying results. Some athletes use carnitine supplements to increase exercise performance, however, the concept of carnitine loading does not appear to be very effective.1 Further, D,L-carnitine competitively inhibits levocarnitine. This inhibition may lead to a deficiency. Prescription forms of levocarnitine were approved by the FDA in 1985 (tablets), 1986 (oral solution), and 1992 (injection).

L-Arginine- Arginine hydrochloride is a synthetic derivative of the essential amino acid L-arginine. Arginine hydrochloride may be used as an aid to the detection of growth hormone deficiency in conditions such as panhypopituitarism, pituitary dwarfism, chromophobe adenoma, postsurgical craniopharyngioma, hypophysectomy, pituitary trauma, and in problems with growth and stature. The drug has also been used in the evaluation of pituitary function in gigantism and acromegaly Further, arginine injection is used to treat high ammonia concentrations in patients with urea cycle disorders. Arginine tablets, which are dietary supplements, have been used to improve exercise capacity in patients with stable angina pectoris.1 Arginine injection was originally approved by the FDA in February 1973.

BCAA INJECTION

Ingredients and dosage strengths of BCAA injection include:

L-Isoleucine 15 mg/mL, L-Leucine 10mg/mL, L-Valine 40 mg/mL Preserved 30 mL vial

L-Isoleucine 15 mg/mL, L-Leucine 10mg/mL, L-Valine 40 mg/mL Preservative Free 30 mL vial

General Information: There are nine essential amino acids which are not made by the body and therefore must be obtained via the diet.

3 of the 9 essential amino acids are:

  • Leucine

  • Isoleucine

  • Valine

These are called branched-chain amino acids (BCAAs) because their molecular structure is branched.

While all other amino acids are broken down in the liver; BCAAs are metabolized primarily in lean body mass tissue.1 Because of this, they could help improve exercise performance and also reduce the rate of lean body mass break down.2

BCAA supplementation may promote lean body mass protein synthesis and also increase lean body mass in individuals who consume a low protein diet.3 In one study, leucine and valine were found to cause a significant suppression in body weight loss in mice with cachexia (body-wasting). Both of these BCAAs caused a significant increase in muscle tissue, through an increase in protein synthesis and a decrease in degradation.4

BCAA supplementation may also be effective in preventing fatigue in athletes and physically active people by halting a decline in serum BCAA levels which can occur during physical exertion. A decline in serum BCAA levels typically causes the influx of tryptophan into the brain, which is followed by increased serotonin production - which may result in fatigue.5

The amino acid leucine plays a critical role in the synthesis of muscle protein. Isoleucine plays a vital role by inducing cells to store more glycogen. Valine functions synergistically with the other two BCAAs, to encourage normal growth, repair bodily tissues, regulate blood sugar levels, and supply the body with energy. Valine also stimulates the central nervous system and is required for healthy mental function.6

L-Isoleucine: Isoleucine is the BCAA best known for its role in increasing endurance, helping to repair lean tissue, and encouraging blood clotting at the site of injury. This BCAA has been shown to provide potential benefit for athletes because its primary role in the body is to increase energy and help recovery from strenuous physical activity.7

An isoleucine deficiency can produce symptoms like those of hypoglycemia (low blood sugar), and can include:8

  • Headaches

  • Dizziness

  • Fatigue

  • Depression

  • Confusion

  • Irritability

L-Leucine: Leucine works with the BCAAs isoleucine and valine to help repair lean mass, regulate blood sugar, and maintain the body’s energy levels. L-leucine has also shown to temporarily increase the production of growth hormone.9

Leucine is also an effective BCAA for preventing lean body mass loss because it is metabolized to glucose more quickly than either isoleucine or valine. Increased available glucose inhibits the body having to break down lean body mass for energy during intense exertion.

Leucine is also involved in healing processes in bones, skin, and lean body mass tissue after traumatic injury. Because of this leucine is often administered in nutritional support for people recovering from surgery.9

L-Valine: Valine may help in removing excess nitrogen from the liver and in transporting nitrogen to other tissues in the body as required. Valine has also been studied as an adjunctive nutritional support in people with liver and gallbladder disease caused by alcoholism or drug abuse. Valine has also been studied for reversing alcohol-related brain damage.10

What are the precautions when taking this medicine? According to the most recent research studies; daily intake of BCAAs substantially in excess of the BCAAs contained in dietary sources appears to be safe in humans.11 Excessive oral consumption can cause gastrointestinal discomfort.

Who shouldn’t take this supplement? People who suffer from Maple Sugar Urine Disease (a rare but potentially fatal metabolic disorder) lack an essential enzyme to break down BCAAs and should not use BCAA injection.12

Consuming BCAAs has been linked to lung failure and increased death rates when used in people with ALS (Lou Gehrig’s Disease). If you have ALS, you should not use branched-chain amino acids.13

What are some possible side effects of this medicine? A recent study hasn’t found any side effects associated with taking the recommended dose of BCAAs.14

How is it best taken?  BCAAs can be taken either orally or by intramuscular injection.

What do I do if I miss a dose?  If you do miss a dose; it is best to take it as soon as you remember. But, if it is almost time for the next dose, simply skip the missed one and take the next scheduled dose. Don’t take two doses at the same time.

How should I store this medicine? Store BCAA Injection at between 68°F to 77°F (20°C to 25°C) and keep it away from heat, moisture, and light. Keep all medicines out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

Dosage strengths of Glycine available:

50 mg/mL 30 mL vial

General Information:  Glycine is, structurally, the simplest amino acid that has been discovered. It was one of the earliest amino acids to be isolated from gelatin back in 1820. Glycine is one of the nonessential amino acids for mammals; meaning that they can create it internally from two other amino acids: serine and threonine.1

Glycine is found principally in gelatin and silk fibroin. It’s been used therapeutically as a nutrient, and also functions as a rapid inhibitory neurotransmitter in the central nervous system (CNS).2 Although glycine is both a simple and nonessential amino acid; experimental animals on low-glycine diets show reduced growth.12  The average adult will ingest 3 to 5 grams of glycine daily from dietary sources. 1 Glycine is an amino acid that’s involved in the production of DNA, phospholipids, and collagen. It’s also involved in the release of energy.3

Glycine for joint repair: Glycine plays a vital role in collagen formation. It’s an important component for promoting joint, tendon, and ligament function and growth.4 Roughly 1/3 of collagen in the body is composed of glycine, and collagen is critical for the formation of the connective tissues that keep joints flexible and capable of successfully withstanding shocks.5

Glycine and muscle growth: The body uses glycine during the biosynthesis of creatine; which supplies all muscles with a source of fuel to repair damage and grow stronger.6 It also provides cells with energy due to its role in converting dietary nutrient to help feed muscle tissues and potentially boost:

  • Endurance

  • Strength

  • Performance

Glycine also benefits hormone production and regulation. It helps the body to naturally synthesize steroid hormones essential to regulating both the fat to muscle ratio and control energy expenditure.7

Can have a calming effect on the brain: Glycine will work with other amino acids, including taurine and gamma-amino butyric acid (GABA), to act as an inhibitory neurotransmitter.8 This role in nerve and neurotransmitter functions has implications for improving; sleep quality, mental performance, moods, memory, and behavior. Some evidence suggests that glycine may help reduce hyperactivity in the brain and play an effective role in the treatment and prevention of certain mental disorders, such as learning disabilities, schizophrenia, bipolar disorder, and epilepsy.8 Other studies have demonstrated that glycine can help minimize psychotic symptoms and seizures when used with other supplements as part of a treatment plan for neurological illness.910

Assists digestion: Amino acids, including glycine, help to rebuild the tissue that lines the digestive tract;11 keeping bacteria and food particles contained inside the gut, rather than exiting through tiny openings that pass this matter into the bloodstream where it can trigger an inflammatory response12 Glycine plays a role in forming the two most important substances in the gut lining: collagen and gelatin.1213

Inside the GI tract; glycine will be utilized as a metabolic fuel.14 It’s required in the production of bile (to break down fats), nucleic acids, creatine phosphate and the porphyrins used to break down nutrients.15 It helps move glycogen to the cells for the production of ATP for energy.15 Studies show that glycine may help stabilize blood sugar levels, preventing food cravings and fatigue.16

Aging: Glycine is used to produce glutathione, an antioxidant that prevents cell damage and several signs of aging. A paper published in the American Journal of Clinical Nutrition concluded that; while glutathione deficiency in the elderly occurs because of a distinct reduction in glutathione synthesis; supplementing the diet with the glutathione precursors cysteine and glycine can restore normal glutathione production.17

What is this medicine used for?  Glycine plays a role in:

  • The production of human growth hormone18

  • Preventing sarcopenia (muscle wasting or deterioration)19

  • Improving sleep quality19

  • Mental performance and memory910

  • Protecting skin from signs of aging20

  • Protecting collagen in joints and reducing joint pain21

  • Boosting energy levels15

  • Stabilizing blood sugar16

What are the precautions when taking this medicine? People being treated with clozapine should avoid taking glycine.22

What are some possible side effects of this medicine?  A small number of individuals have reported experiencing slight sedation after using glycine.23

How is it best taken?  Glycine can be taken either orally or by intramuscular injection.

What do I do if I miss a dose? If you do miss a dose; it’s best to take it as soon as you remember. Although, if it’s almost time for the next dose, just skip the missed one and take your next scheduled dose. Don’t take two doses at the same time.

How should I store this medicine? Store glycine at between 68°F to 77°F (20°C to 25°C) and keep it away from heat, moisture, and light. Keep all medicines out of the reach of children. Throw away any unused medicine after the expiration date. Do not flush unused medications or pour down a sink or drain.

Dosage strength of Taurine Injection:

Taurine 50 mg/mL 30 mL vial

General Information: Studies strongly suggest that taurine supplementation, even when taken short-term; may support better physical function, mitigate the cardiovascular risks that can be present after exercising, and improve issues associated with heart failure.12

Taurine may accomplish this by reducing inflammation and lowering blood pressure. Some research suggests that taurine may calm the nervous system and even improve the function of the left ventricle of the heart. 

 

Although more studies must be conducted to confirm these benefits; the research already conducted is promising for anyone concerned with cardiac health or suffering from heart disease.12

 

A meta-analysis review published in the journal Food & Function found, after analyzing animal and human studies; that taurine has an effective action against the symptoms of metabolic syndrome.3

 

The study found that Taurine appears to:

  • Reduce triglycerides  

  • Prevent obesity,

  • Improving insulin resistance to

  • Regulate glucose metabolism,

  • Lower cholesterol

  • Reduce blood pressure

Taurine might also help heal the damage from periodontal disease. Patients with chronic periodontitis were observed to determine if taurine could help the healing process.  It was determined that taurine significantly improved the healing process. According to this research, it may have done so by enhancing levels of lipid peroxidation products and antioxidant enzymes.4

 

A study conducted at the University of Stirling evaluated athletes who ran middle distance races before and after they consumed supplemental taurine. The test-subjects consumed 1,000 milligrams of taurine two hours before running, and they were checked to confirm that there was no effect on the athlete’s respiratory system, heart rate or blood lactate levels. Afterward, 90% of the runners showed faster times. According to this research; there is a 99.3% chance that taurine was responsible for the improved performance of the athletes during the time trial.5

 

Other studies indicate that taurine may have a powerful mood-boosting effect when combined with caffeine. Scientists have found strong evidence that a combination of taurine and caffeine may improve mood and possibly boost cognitive performance.6

 

Taurine is one of the most copious amino acids in the human eye; where it exceeds the concentration of any other amino acid. Consequently, recent studies have found that maintaining high levels of taurine is crucial to prevent the degeneration of cells in the eye.7

 

What is this medicine used for? Taurine may be taken to:

  • Maintain cognitive performance

  • Support a healthy metabolism,

  • As a powerful antioxidant

  • Support eye health

Who shouldn’t take this supplement? Due to a lack of studies on the safety of taurine during pregnancy and breastfeeding it would be best for women who are pregnant or nursing to avoid using it.

 

What are the precautions when taking this medicine? An oral dose of about 3,000 milligrams per day of taurine is considered safe. But, more studies are required to confirm this. Furthermore, the kidneys will excrete excess taurine; since this could put an unusual strain on the kidneys, (particularly for anyone dealing with kidney problems) you should discuss taking large doses of this supplement with your doctor first.8

 

What are some possible side effects of this medicine? Taurine is an amino acid that the body synthesizes naturally and is considered a nonessential amino acid. As a naturally produced substance in the body; studies on Taurine have confirmed few adverse effects when consumed in doses of up to 3 grams.9

 

How is it best taken? Taurine can be administered intravenously or injected intramuscularly.

 

What do I do if I miss a dose? If you do miss a dose; it’s best to take it as soon as you remember. Although, if it’s almost time for the next dose, just skip the missed one and take your next scheduled dose. Don’t take two doses at the same time.

 

How should I store this medicine? Store Taurine at between 68°F to 77°F (20°C to 25°C) and keep it away from heat, moisture, and light. Keep all medicines out of the reach of children. Throw away any unused medicine after the expiration date. Do not flush unused medications or pour down a sink or drain.

 

General statements: Do not share or take anyone else's medicine. Talk with your healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins. This patient information summarizes the most important information about your medication; if you would like more information, talk with your doctor.

 

Dosage strengths of Tri-Amino available:

30 mL vial. L-Arginine HCl 100 mg/mL, L-Citruline 100 mg/mL, L-Ornithine 100 mg/mL

General Information: Tri-Amino injection is a combination of three conditional, non-essential amino acids: L-Arginine, L-Citrulline, and L-Ornithine that can play a critical role in:

  • Cardiovascular health

  • Vasodilation (blood flow)

  • Erectile function

  • General health and longevity

The Difference between Essential, Non-essential, and Conditional Amino Acids

 

Amino Acid Basics: Amino acids are separated into three categories: essential, nonessential, and conditional.1

 

Essential amino acids: Essential amino acids are the amino acids that are present in foods - since the body cannot produce them endogenously.

 

Nine out of the twenty amino acids necessary for health are essential, but adults need get only eight of them from dietary sources: valine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine and tryptophan. The 9th amino acid is histidine and it is only essential in infants. The body cannot store amino acids, so a regular daily supply of these essential building blocks of protein is needed.1

 

Non-essential and conditional Amino acids: Nonessential is a misnomer because these amino acids do fill essential roles. They are considered non-essential because the body can synthesize them, not because they are not essential to health.2

 

Of these eleven non-essential amino acids, eight are referred to as conditional amino acids because when the body is ill or under stress, it may not be capable of producing enough of these amino acids to meet its needs.2

 

The conditional amino acids include; arginine, ornithine, glutamine, tyrosine, cysteine, glycine, proline, and serine. 

 

Amino acids can be used by the body to produce energy, but their primary function is to build proteins. Certain amino acids may also fill non-protein-building functions; such as in the formation of neurotransmitters or hormones.3

 

Each of the body’s twenty amino acids has a unique chemical structure that dictates how they’ll be utilized. A protein will consist of fifty to two-thousand different amino acids that are linked together in a particular sequence according to specific (genetic) instructions.

 

What is this medicine used for? Tri-amino Injection is used to supplement the body with two conditional amino acids: l-arginine and l-ornithine, plus citrulline – which in a study published in the Journal Critical Care was identified as a possibly critical biomarker and pharmaconutrient.4 These amino acids have been shown by various research studies to play a potentially vital role in supporting cardiovascular health, healthy blood flow,56 and consequently, erectile dysfunction caused by vascular issues and poor circulation.

 

L-Arginine: L-arginine is an amino acid that can be obtained from the diet and is necessary for the body to synthesize proteins. Arginine is converted by the body into another important substance - nitric oxide.7

 

Nitric oxide relaxes blood vessels which is vital for healthy blood flow to the heart and organs throughout the body (including genitals). Nitric oxide aids blood vessels to maintain the flexibility needed for unrestricted blood flow.7 This improved blood flow helps maintain both optimal blood pressure and a proper sexual function.

 

L-arginine has been studied in clinical researched aimed at improving heart and blood vessel conditions that include:8

  • Congestive heart failure

  • Angina pectoris (chest pain)

  • Hypertension

  • Erectile dysfunction (ED)

  • Coronary artery disease

L-arginine has been used in several studies including recurring pain in the legs from blocked arteries, decreased mental capacity due to age (dementia), and male infertility.91011

 

L-arginine has been used in combination with various over-the-counter (OTC) and prescription medications for several conditions. For example: L-arginine has been used with ibuprofen to treat the symptoms of migraine headaches and combined with conventional chemotherapy drugs in the treatment of breast cancer.1213

 

In addition to other amino acids, arginine has been used to treat cachexia (wasting) in people with cancer and with fish oil and certain supplements to help reduce infections, improve healing, and shorten recovery times after surgery.1415 It has also been used in protocols used to diagnose growth hormone deficiency since it may stimulate the release of that hormone.

 

L-Ornithine: L-ornithine is another nitrogen precursor like arginine. It is also the amino acid used in the body’s urea cycle, which makes it possible to eliminate excess nitrogen (ammonia) from the body.16

 

Ammonia is the waste product of normal cellular metabolism. It becomes toxic when it accumulates in the body. L-ornithine is the catalyst in a process that changes ammonia into urea, which is eliminated by urination. The highest concentration of L-ornithine is found in connective tissues like the skin.17

 

Ornithine is reduced to arginine in the body, but this will usually occur very slowly, making the combination of arginine and ornithine potentially synergistic.18

 

Preliminary research shows that supplements containing l-ornithine may improve athletic performance, such as; speed, strength, and power. Studies have also shown that l-ornithine may help to support healthy wound recovery; this benefit is attributed to the role of l-ornithine in producing collagen.18 There is evidence that l-ornithine may act to decrease anxiety levels when combined with caffeine, possibly because l-ornithine has the ability to cross the blood-brain barrier.19

 

L-Citrulline: L-citrulline is an amino acid that boosts the production of nitric oxide in the body.20 Nitric oxide acts to relax the arteries for improved blood flow throughout the body.  

 

Some studies indicate that l-citrulline may help people with diabetes that have circulatory issues such as slow wound healing.21 Because of its effects in increasing nitric oxide production, l-citrulline supplementation may improve dilation of blood vessels and blood flow that can improve the symptoms of mild to moderate degrees of erectile dysfunction.22

 

Who shouldn’t take this supplement? There is little research into the use of the ingredients in Tri-Amino Injection in pregnant or nursing women. Due to this it is not advised the pregnant women or mothers who are nursing use this supplement.

 

What are the precautions when taking this medicine? The amino acids in Tri-Amino Injection may affect how certain drugs work in the body. Don’t take this supplement if you are using nitrates to treat heart disease, any type of medicine for hypertension or ED drugs like sildenafil, tadalafil or vardenafil.23 The combination of Tri Amino Injection with these drugs could result in a dangerous drop in blood pressure.24

 

What are some possible side effects of this medicine?  There are no reported side effects of taking the recommended dosage of the amino acids arginine, ornithine or citrulline.

 

How is it best taken?  Tri Amino Injection may be taken via intramuscular, subcutaneous, or intravenous injection.

 

What do I do if I miss a dose? If you do miss a dose; it is best to take it as soon as you remember. Although, if it is almost time for the next dose, just skip the missed one and take your next scheduled dose. Don’t take two doses at the same time.

 

How should I store this medicine? Store Tri-Amino Injection at between 68°F to 77°F (20°C to 25°C) and keep it away from heat, moisture, and light. Keep all medicines out of the reach of children. Throw away any unused medicine after the expiration date. Do not flush unused medications or pour down a sink or drain.

 

General statements: Do not share or take anyone else's medicine. Talk with your healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins. This patient information summarizes the most important information about your medication; if you would like more information, talk with your doctor.